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文献信息

Comprehensive characterization of the in vitro and in vivo metabolites of geniposide in rats using ultra-high-performance liquid chromatography coupled with linear ion trap–Orbitrap mass spectrometer

期刊名:Xenobiotica
文献编号:
文献地址: http://www.tandfonline.com/doi/abs/10.3109/00498254.2015.1079746#.Vf_TivnvPIU
发表日期:02 Sep 2015


?Yun Li, Wei Caiab, Qian Cai, Yanyun Che,Baosheng Zhao & Jiayu Zhang

Abstract

  1. ?Geniposide (genipin 1-O-glucose), one of the major bioactive constituents isolated from Fructus Gardeniae, possesses many biological activities. In this study, an efficient strategy was developed using ultra-high-performance liquid chromatography coupled with linear ion trap–Orbitrap mass spectrometer (UPLC–LTQ–Orbitrap) to profile the in vitro and in vivo metabolic patterns of geniposide in rat liver microsomes (RLMs), plasma, urine, and various tissues. And post-acquisition data-mining methods including extracted ion chromatogram (EIC), multiple mass defect filters (MMDF), fragment ion searching (FISh), and isotope pattern filtering (IPF) were adopted to characterize the known and unknown metabolites.

   geniposide was purchased from Chengdu Biopurify    Phytochemicals Ltd. (Chengdu, China).

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