我的账户 7×24小时客服热线:400-829-7929 语言:
热门产品: 人参皂苷Rh2,人参皂苷Rg3,胡萝卜苷, 木犀草苷
产品分类
在线咨询
联系电话:
销售:
400-829-7929(7*24小时)
028-82633860
028-82633397 
028-
82633165
技术服务和产品定制:
028-82633987
在线服务:  
沈帅 
文静  点击这里给我发消息
贺丹丹  
点击这里给我发消息
      
文献信息

Ameliorating the Effect of Astragaloside IV on Learning and Memory Deficit after Chronic Cerebral Hypoperfusion in Rats

期刊名:Molecules
文献编号:
文献地址: http://www.mdpi.com/1420-3049/20/2/1904/htm
发表日期:23 January 2015

Ameliorating the Effect of Astragaloside IV on Learning and Memory Deficit after Chronic Cerebral Hypoperfusion in Rats

Sooyong Kim , Il-Hwan Kang , Jung-Bum Nam , Yoonchul Cho , Doo-Young Chung , Seung-Hwan Kim , Jeong-Soo Kim , Yong-Deok Cho , Eun-Ki Hong , Nak-Won Sohn and Jung-Won Shin

Abstract

Astragaloside IV (AS-IV) has been reported to have a prominent antioxidant effect and was proposed as a promising agent for the prevention of neurodegenerative disorders accompanied by cognitive impairment. The present study investigated the ameliorating effect of AS-IV on learning and memory deficits induced by chronic cerebral hypoperfusion in rats. Rats were treated with two doses of AS-IV (10 and 20 mg/kg, i.p.) daily for 28 days starting from the 5th week after permanent bilateral common carotid artery occlusion. AS-IV treatment (at dose of 20 mg/kg) significantly improved the spatial learning and memory deficits assessed using the Morris water maze test in rats with chronic cerebral hypoperfusion. AS-IV significantly attenuated neuronal apoptosis as well as the levels of superoxide dismutase and lipid peroxidation markers, including malondialdehyde and 4-hydroxy-2-nonenal, in the hippocampus. AS-IV also significantly reduced 8-hydroxy-2’-deoxyguanosine expression, a maker of oxidative DNA damage, while significantly inhibited the astrocyte and microglia activation in the hippocampus. The results indicate that AS-IV has therapeutic potential for the prevention of dementia caused by cerebral hypoperfusion and suggest that the ameliorating effect of AS-IV on learning and memory deficits might be the result of suppressing neuronal apoptosis and

Astragaloside IV (AS-IV) (from Astragalus membranaceus; C41H68O14;Figure1A) was purchased from Biopurify Phytochemicals (Chengdu, China).

相关产品