我的账户 7×24小时客服热线:400-829-7929 语言:
热门产品: 人参皂苷Rh2,人参皂苷Rg3,胡萝卜苷, 木犀草苷
产品分类
在线咨询
联系电话:
销售:
400-829-7929(7*24小时)
028-82633860
028-82633397 
028-
82633165
技术服务和产品定制:
028-82633987
在线服务:  
沈帅 
文静  点击这里给我发消息
贺丹丹  
点击这里给我发消息
      
文献信息

In vivo protective effects of 6‑gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti‑apoptotic pathways

期刊名:BIOMEDICAL REPORTS 2
文献编号:
文献地址: https://scholar.google.com/scholar_url?url=https://www.spandidos-publications.com/10.3892/br.2024.1773/download&hl=zh-CN&sa=X&d=6176156577524793344&ei=J-oRZsrnLO-_6rQPzc-GiAI&scisig=AFWwaebC9NlBLMc2WeJLtfqey0dy&oi=scholaralrt&hist=P1l9U8wAAAAJ:5602017072534772868:AFWwaeaNlribOCTJHjZC3KEvdiTK&html=&pos=2&folt=kw
发表日期:March 22, 2024
Stroke is an important medical problem in devel‑
oping countries, characterized by a sudden disruption of blood
supply to the brain, either through occlusion or hemorrhage.
It is a major cause of neurological impairment, resulting in
high medical costs. The present study examined the effect of
6‑gingerol on morphological changes, antioxidant defenses, and
the anti‑apoptotic factors p38 mitogen‑activated protein kinase
(MAPK) and mitofusin (Mfn)2, in a rat model of focal cerebral
ischemia. A total of 60 healthy male Wistar rats were randomly
allocated into six groups: Control, right middle cerebral artery
occlusion (Rt.MCAO) + vehicle, Rt.MCAO + piracetam, and
Rt.MCAO + 6‑Gin 5, 10 and 20 mg/kg BW groups. The results
indicated that 6‑gingerol treatment for a duration of 7 days
reverses morphological alterations, enhances catalase and
glutathione peroxidase activities, reduces Bax, caspase‑3 and
MAPK expression, and increases Bcl‑xL and Mfn2 expres‑
sion in the cortex and hippocampus. In conclusion, 6‑gingerol
demonstrated significant in vivo effectiveness in mitigating
pathological changes induced by cerebral ischemia. This
beneficial effect is attributed, at least in part, to preservation of
antioxidant defenses and activation of anti‑apoptotic pathways.
相关产品