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文献信息

Measurement and Correlation of Solubility of Theobromine, Theophylline, and Caffeine in Water and Organic Solvents at Various Temperatures

期刊名:Journal of Chemical & engineering data
文献编号:
文献地址: http://pubs.acs.org/doi/abs/10.1021/acs.jced.7b00065
发表日期:June 27, 2017
Abstract Image

The solubility of theobromine, theophylline, and caffeine in water and five organic solvents including methanol, ethanol, 1-propanol, ethyl acetate, and acetone was determined by a high performance liquid chromatography method at T = (288.15 to 328.15) K and atmospheric pressure. It was found that the solubility of theobromine, theophylline, and caffeine in these solvents increased with increasing temperature. The empirical Apelblat equation and universal quasichemical model were used to correlate the experimental solubility. The results showed that both models can satisfactorily correlate the solubility data. The crystal forms of the solutes in equilibrium with the saturated solution were analyzed using scanning electron microscopy and powder X-ray diffraction.

... It was dried in an air-circulating oven (Jinghong DNG-9070A, Shanghai, China) at T = 368.2 K
for 4 h. The purity (≥98%) was determined by HPLC. The reference substance of caffeine
(≥98%) was purchased from Chengdu Biopurify Phytochemicals Ltd. (China). ...

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