我的账户 7×24小时客服热线:400-829-7929 语言:
热门产品: 人参皂苷Rh2,人参皂苷Rg3,胡萝卜苷, 木犀草苷
产品分类
在线咨询
联系电话:
销售:
400-829-7929(7*24小时)
028-82633860
028-82633397 
028-
82633165
技术服务和产品定制:
028-82633987
在线服务:  
沈帅 
文静  点击这里给我发消息
贺丹丹  
点击这里给我发消息
      
文献信息

Antioxidant activity-guided phytochemical investigation ofArtemisia gmelinii Webb. ex Stechm.: Isolation and spectroscopic challenges of 3,5-O-dicaffeoyl (epi) quinic acid and its ethyl ester

期刊名:J PHARMACEUT BIOMED
文献编号:
文献地址: http://www.sciencedirect.com/science/article/pii/S0731708511005887
发表日期:5 February 2012

Antioxidant activity-guided phytochemical investigation ofArtemisia gmelinii Webb. ex Stechm.: Isolation and spectroscopic challenges of 3,5-O-dicaffeoyl (epi) quinic acid and its ethyl ester

árpád K?ncz?l, Zoltán Béni, Márta Meszlényi Sipos, Attila Rill, Viktor Hád,  Judit Hohmann, Imre Máthé, Csaba Szántay Jr., Gy?rgy Miklós Keser?, Gy?rgy Tibor Balogh, 

Abstract

Although Artemisia gmelinii Webb. ex Stechm. has long been used in south and south-east Asia to treat many kinds of inflammatory diseases, up until now its bioactivity-coupled phytochemical characterization has not been reported. We identified one fraction of the methanolic extract of A. gmelinii as a hit in our antioxidant screening (DPPH) campaign. In order to identify the active radical scavenger components of the extract, a DPPH-HPLC spiking assay was carried out. Out of six detected known compounds caffeic acid (1) and scopoletin (4) had already been identified in the plant, but four of them, namely chlorogenic acid (2), 4-O-caffeoylquinic acid (3), luteolin-7-O-glucoside (5), and apigenin-7-O-glucoside (6) are first described here. Moreover, the two most active compounds of the mixture, 3,5-O-dicaffeoylquinic acid (7) and its ethyl ester derivative (8) were isolated with preparative HPLC. The spectroscopic identification of 7 and 8 presented a surprising challenge due to literature ambiguities. These questions are discussed in detail.

 4-O-Caffeoylquinic acid was purchased from Biopurify Phytochemicals Ltd. (Chengdu, Sichuan, China).

相关产品